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samantha2 opt250Sturge-Weber Syndrome (encephelotrigeminal angiomatosis) is a congenital, non-familial disorder of unknown incidence and cause. It is characterized by a congenital facial birthmark and neurological abnormalities. Other symptoms associated with Sturge-Weber can include eye and internal organ irregularities. Each case of Sturge-Weber Syndrome is unique and exhibits the characterizing findings to varying degrees.



About Sturge-Weber Syndrome


Sturge-Weber Syndrome (encephelotrigeminal angiomatosis) is a congenital, non-familial disorder of unknown incidence and cause. It is characterized by a congenital facial birthmark and neurological abnormalities. Other symptoms associated with Sturge-Weber can include eye and internal organ irregularities. Each case of Sturge-Weber Syndrome is unique and exhibits the characterizing findings to varying degrees.


Facial Birthmark

The most apparent indication of Sturge-Weber Syndrome is a facial birthmark or "Port Wine Stain" present at birth and typically involving at least one upper eyelid and the forehead. Much variation in the size of the stain has been reported and may be limited to one side of the face or may involve both sides. The birthmark, varying from light pink to deep purple, is due to an overabundance of capillaries just beneath the surface of the involved skin. In persons with dark pigmentation, the stain may be difficult to recognize. In rare instances, there is an absence of a Port Wine Birthmark.

Neurological Abnormalities

Neurological concerns relate to the development of excessive blood vessel growth on the surface of the brain (angiomas). These are located typically on the back (occipital) region of the brain on the same side as the port wine birthmark. These angiomas create abnormal conditions for brain function in the region. Seizure activity is the most common early problem, often starting by one year of age. The convulsions usually appear on the opposite side of the body from the Port Wine Stain and vary in severity. Vigorous attempts are made to control the seizures with medication. A weakening or loss of the use of one side of the body (hemiparesis), may develop opposite to the port wine stain. Developmental delay of motor and cognitive skills may also occur to varying degrees.

Other Manifestations

Increased pressure within the eye (glaucoma) is another condition which can be present at birth or develop later. The incidence of glaucoma in patients with Sturge-Weber is approximately 70% and 40% for choroidal lesions. The glaucoma is usually restricted to the eye which has the stain involvement. Enlarging of the eye (buphthalmos) can also occur in the eye which has been affected by the stain. Multiple other body organs are rarely affected in Sturge-Weber syndrome. Infants affected with Sturge-Weber Syndrome are often monitored by a pediatrician, neurologist, ophthalmologist and dermatologist.

Treatment

Laser treatment is available to lighten and or remove port wine birthmarks in children as young as one month of age. Anti-convulsants are used to control the seizures. VNS implants and brain surgery can be also be utilized for seizure management. Eye drops or oral medications are used to control the glaucoma. Should topical or oral medications not prove effective, the next step would be surgery.

In 1992, E. Steve Roach, MD classified the SWS spectrum, delineating for the first time the varying degrees of involvement previously noted in this condition.

golf opt180Type 1

he most common, this type involves both facial and leptomenigeal (brain) angiomas (vascular malformations) and may involve glaucoma. Seizures usually occur within the first year of life, as a result of the brain involvement. The ocular involvement is normally noted within the first year of life, as well. The white portion of the eye may appear "bloodshot" as a result of the over-proliferation of blood vessels on the eye. In rare cases, the facial and brain involvement are bilateral (involving both sides of the head). Mental and physical development can be impaired to varying degrees, depending on the amount of vascular birthmark throughout the brain and eye.

 

 

 

 

 

 

 

 

gloria2 optType 2

This type involves a facial angioma and the possibility of glaucoma, but no evidence of intracranial disease. There is no specific time-frame for the exhibition of symptoms beyond the initial recognition of the facial PWS. Throughout the life of the individual, interrelated symptoms may manifest in glaucoma, cerebral blood flow abnormalities, headaches, and various other complications. Additional research needs to be conducted on this type of SWS to determine the course of the syndrome over its natural progression.

 

 

 

 

 

 

 

 

 

Carley opt180Type 3

This type of SWS is commonly noted to have a leptomeningeal angioma, with no facial involvement and usually no development of glaucoma. Commonly referred to as forme fruste, this type is identified through brain scans. It can also be confused with other diagnoses prior to a brain scan with contrasting agent. While social stigma is lessened by the absence of PWB, the unknown natural course of the syndrome is still frustrating for parents and professionals treating the condition.

 

 

 

 

 

 

 

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Resources 

 

 

 

 

 

Printed Materials Available on the Marketplace

  • Emergency Room Guide for SWS: The major neurological features of patients with Sturge-Weber syndrome include seizures, headache, focal neurologic deficits and cognitive and psychological impairment.
  • 2nd Edition SWS Textbook:  The latest information and insight into Sturge-Weber syndrome. Whether it’s for a reason, a season, or a lifetime, this textbook needs to be on your library shelf!  Whether it’s for a reason, a season, or a lifetime, this textbook needs to be on your library shelf! The second edition describes newer imaging modalities and updates information about the clinical findings of Sturge-Weber syndrome and available patient resources.
  • SWS Guidebook for Teens: A four color soft cover booklet geared toward the issues of children ages 13-17.  In addition to addressing the medical issues faced by this group, such as seizures, glaucoma, laser treatments and medication, it will also focus on the social and emotional issues such as friendship, bullying, self-esteem, dating and family issues.
  • Someone Special: This 20 page booklet was written for children with a birthmark, ages 2 to 7 and their parents. While viewing pictures of others with birthmarks, readers are encouraged to celebrate their talents.
  • A Kids Guide to SWS: Abundantly illustrated, gives elementary and middle school children solid facts about SWS. Also includes chapters on self-esteem, relationships and bullying. Also useful for teachers, classmates and family members.
  • Color Me Different Color Me the Same: Coloring book gives school age children a fun activity along with an important message about accepting other children who look different. Also discusses the manifestations of SWS in easy, kid-friendly language.
  • Check it out CardsCheck it Out Cards are handy resource to answer those spontaneous questions you encounter in public situations. It also directs the recipient to the SWF website for more information. Cards are sold in packs of 25. 

 

  

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Sturge-Weber Sites Around the Globe